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Temperature dependence of leukemic cell destruction by alkyl-lysophospholipids (NSC 324368)

Andreesen, Reinhard and Modolell, M. and Oepke, G. H. and Munder, P. G. (1983) Temperature dependence of leukemic cell destruction by alkyl-lysophospholipids (NSC 324368). Experimental hematology 11 (6), pp. 564-70.

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Abstract

Alkyl-analogs (ALP) of 2-lysophosphatidylcholine induce a progressive destruction of neoplastic cells by interfering with the continuous turnover of membrane phospholipids. Using leukemic blast cells from patients with acute forms of leukemia the effect of temperature was evaluated. It was found that temperature strongly influences the cytotoxic activity of ALP. High temperatures potentiate ...

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Item Type:Article
Date:1983
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
6617791PubMed ID
Classification:
NotationType
Acute DiseaseMESH
Hematopoietic Stem Cells/drug effectsMESH
HumansMESH
Leukemia/drug therapyMESH
LysophospholipidsMESH
Membrane Lipids/metabolismMESH
Phospholipids/therapeutic useMESH
TemperatureMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:13 Apr 2010 05:09
Last Modified:13 Apr 2010 05:09
Item ID:14188
Owner Only: item control page
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