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Macrophage colony-stimulating factor is required for human monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro

Brugger, W. and Kreutz, Marina and Andreesen, Reinhard (1991) Macrophage colony-stimulating factor is required for human monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro. Journal of leukocyte biology 49 (5), pp. 483-488.

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Abstract

Functional competence as well as phenotype heterogeneity of macrophages depend on the completion of their maturation pathway. Differentiation of committed myeloid progenitor cells is induced by colony-stimulating factors (CSF), but no consistent data exist on which factor(s) induce the terminal maturation from the circulating blood monocyte to the mature macrophage. In vitro, monocyte to ...

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Item Type:Article
Date:1991
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
2016569PubMed ID
Classification:
NotationType
AntibodiesMESH
Cell Differentiation/drug effectsMESH
Cell Survival/drug effectsMESH
Cells, CulturedMESH
Cytokines/pharmacologyMESH
HumansMESH
KineticsMESH
Leukocytes, Mononuclear/drug effectsMESH
Macrophage Colony-Stimulating Factor/pharmacologyMESH
Macrophages/drug effectsMESH
Neutralization TestsMESH
Recombinant Proteins/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:24
Last Modified:13 Mar 2014 17:59
Item ID:14269
Owner Only: item control page

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