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Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation

Konur, A. and Kreutz, M. and Knüchel, R. and Krause, S. W. and Andreesen, Reinhard (1996) Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation. International journal of cancer. Journal international du cancer 66 (5), pp. 645-52.

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Abstract

Here we report on an experimental system for generating TAM in vitro by culturing human MO and MO-derived macrophages (MAC) within 3-dimensional multicellular tumor spheroids (MCS). MO as well as MO-derived MAC migrate into tumor spheroids and spread throughout the entire spheroid within 16 hr. In contrast, fibroblast-spheroids were not infiltrated. The regular expression of MAC ...

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Item Type:Article
Date:1996
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
8647627PubMed ID
10.1002/(SICI)1097-0215(19960529)66:5<645::AID-IJC11>3.0.CO;2-3DOI
Classification:
NotationType
Antigens, Neoplasm/analysisMESH
Base SequenceMESH
Cell Differentiation/physiologyMESH
Coculture TechniquesMESH
Cytokines/biosynthesisMESH
HumansMESH
Macrophage Activation/physiologyMESH
Macrophages/metabolismMESH
Metalloendopeptidases/analysisMESH
Molecular Sequence DataMESH
Monocytes/cytologyMESH
PhenotypeMESH
Polymerase Chain ReactionMESH
RNA, Messenger/metabolismMESH
Spheroids, CellularMESH
Transcription, GeneticMESH
Tumor Cells, CulturedMESH
Tumor Necrosis Factor-alpha/biosynthesisMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:00
Last Modified:14 Apr 2010 05:00
Item ID:14302
Owner Only: item control page
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