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The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation

Lübbert, M. and Henschler, R. and Kreutz, M. and Andreesen, Reinhard and Mertelsmann, R. and Herrmann, F. (1997) The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 11 (7), pp. 990-7.

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Abstract

The lysozyme (LZM) gene provides a very useful model for studies of phagocyte maturation, because its protein synthesis is increased during myelopoiesis and thus most abundant in terminally differentiated and activated phagoyctes. LZM gene expression and DNA methylation were examined in various normal and transformed hematopoietic cells. Two shifts toward LZM gene demethylation coincided with ...

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Item Type:Article
Date:1997
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9204980PubMed ID
Classification:
NotationType
Cell DifferentiationMESH
DNA MethylationMESH
DealkylationMESH
Gene Expression Regulation, EnzymologicMESH
HematopoiesisMESH
HumansMESH
Muramidase/geneticsMESH
Phagocytes/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:38
Last Modified:15 Apr 2010 05:38
Item ID:14317
Owner Only: item control page
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