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Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

Holtrich, U. and Wolf, G. and Yuan, J. and Bereiter-Hahn, J. and Karn, T. and Weiler, M. and Kauselmann, G. and Rehli, M. and Andreesen, Reinhard and Kaufmann, M. and Kuhl, D. and Strebhardt, K. (2000) Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Oncogene 19 (42), pp. 4832-9.

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Abstract

Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-associated polo-like kinase (Plk), tissue distribution of Fnk transcripts and expression kinetics ...

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Item Type:Article
Date:2000
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
11039900PubMed ID
10.1038/sj.onc.1203845DOI
Classification:
NotationType
Actins/metabolismMESH
AdultMESH
AnimalsMESH
Blood Cells/enzymologyMESH
COS CellsMESH
Calcineurin/chemistryMESH
Calcium/physiologyMESH
Calcium-Binding ProteinsMESH
Calmodulin/chemistryMESH
Carrier Proteins/metabolismMESH
Cell Adhesion/geneticsMESH
Cell Cycle ProteinsMESH
Cell DifferentiationMESH
Cell Membrane/enzymologyMESH
Cercopithecus aethiopsMESH
Culture Media/pharmacologyMESH
Culture Media, Serum-Free/pharmacologyMESH
Cytoskeleton/ultrastructureMESH
DNA, Complementary/geneticsMESH
Gene Expression Regulation, DevelopmentalMESH
HL-60 CellsMESH
HumansMESH
Macrophages/enzymologyMESH
Monocytes/enzymologyMESH
Multigene FamilyMESH
Polymerase Chain ReactionMESH
Protein Kinases/geneticsMESH
Protein-Serine-Threonine Kinases/geneticsMESH
Proto-Oncogene ProteinsMESH
RNA, Messenger/biosynthesisMESH
Recombinant Fusion Proteins/physiologyMESH
Signal TransductionMESH
Transcription, GeneticMESH
TransfectionMESH
Two-Hybrid System TechniquesMESH
U937 CellsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:19
Last Modified:15 Apr 2010 05:19
Item ID:14346
Owner Only: item control page
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