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PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene

Rehli, M. and Poltorak, A. and Schwarzfischer, L. and Krause, S. W. and Andreesen, Reinhard and Beutler, B. (2000) PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. The Journal of biological chemistry 275 (13), pp. 9773-81.

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Abstract

The protein product of the Toll-like receptor (TLR) 4 gene has been implicated in the signal transduction events induced by lipopolysaccharide (LPS). In mice, destructive mutations of Tlr4 impede the normal response to LPS and cause a high susceptibility to Gram-negative infection. Expression of TLR4 mRNA in humans is restricted to a small number of cell types, including LPS-responsive myeloid ...

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Item Type:Article
Date:2000
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
10734131PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Base SequenceMESH
Bone Marrow/metabolismMESH
Cloning, MolecularMESH
DNAMESH
Drosophila ProteinsMESH
Gene Expression Regulation/physiologyMESH
HumansMESH
Interferon Regulatory FactorsMESH
Membrane Glycoproteins/geneticsMESH
MiceMESH
Molecular Sequence DataMESH
Mutagenesis, Site-DirectedMESH
Promoter Regions, GeneticMESH
Protein BindingMESH
Proto-Oncogene Proteins/physiologyMESH
Receptors, Cell Surface/geneticsMESH
Repressor Proteins/physiologyMESH
Sequence Homology, Nucleic AcidMESH
Toll-Like Receptor 4MESH
Toll-Like ReceptorsMESH
Trans-Activators/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:16
Last Modified:19 Apr 2010 06:36
Item ID:14354
Owner Only: item control page
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