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Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors

Eisert, V. and Kreutz, M. and Becker, K. and Königs, C. and Alex, U. and Rübsamen-Waigmann, H. and Andreesen, Reinhard and von Briesen, H. (2001) Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors. Virology 286 (1), pp. 31-44.

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Abstract

We analyzed parameters influencing HIV-1 infectibility of cells of the monocyte/macrophage lineage (MO/MAC) isolated from different healthy donors. The proportion of in vitro-infected cells and replication kinetics in different donor MAC ranged from 0.03 to 99% p24 antigen-positive MAC and from undetectable RT activity up to 5 x 10(6) cpm/ml/90 min, respectively. As a quantitative measurement for ...

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Item Type:Article
Date:2001
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
11448156PubMed ID
10.1006/viro.2001.0940DOI
Classification:
NotationType
Blood DonorsMESH
Genetic VariationMESH
HIV-1/physiologyMESH
HumansMESH
Macrophages/virologyMESH
Receptors, HIV/physiologyMESH
Virus ReplicationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:15
Last Modified:15 Apr 2010 05:15
Item ID:14355
Owner Only: item control page
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