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Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells

Heinz, Sven ; Krause, Stefan W. ; Gabrielli, Franco ; Wagner, Harald M. ; Andreesen, Reinhard ; Rehli, Michael



Zusammenfassung

We used representational difference analysis to discover new genes with specific expression in dendritic cells. Among other genes, we identified HEP27, encoding a member of the short chain alcohol dehydrogenase/reductase family to be upregulated during monocyte to dendritic cell differentiation. Originally cloned from hepatocellular carcinoma cells (HepG2), HEP27 was exclusively expressed in ...

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