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Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation

Gerbitz, Armin and Ewing, Patricia and Wilke, Andrea and Schubert, Thomas and Eissner, Günther and Dietl, Barbara and Andreesen, Reinhard and Cooke, Kenneth R. and Holler, Ernst (2004) Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 10 (7), pp. 461-72.

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Abstract

Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15205667PubMed ID
10.1016/j.bbmt.2004.04.001DOI
Classification:
NotationType
AnimalsMESH
Antigens, CD/immunologyMESH
Bone Marrow Transplantation/immunologyMESH
Cobalt/administration & dosageMESH
Cytokines/bloodMESH
Enzyme Induction/immunologyMESH
Graft vs Host Disease/mortalityMESH
Heme Oxygenase (Decyclizing)/immunologyMESH
Heme Oxygenase-1MESH
Intestinal Mucosa/pathologyMESH
Liver/pathologyMESH
Lymphocyte Activation/immunologyMESH
Membrane ProteinsMESH
MiceMESH
Protoporphyrins/administration & dosageMESH
Spleen/pathologyMESH
Transplantation Conditioning/methodsMESH
Transplantation, HomologousMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:45
Last Modified:20 Apr 2010 05:45
Item ID:14425
Owner Only: item control page
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