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High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.

Meidenbauer, Norbert and Zippelius, Alfred and Pittet, Mikaël J and Laumer, Monika and Vogl, Sandra and Heymann, Jana and Rehli, Michael and Seliger, Barbara and Schwarz, Stephan and Le Gal, Frederique-Anne and Dietrich, Pierre Y and Andreesen, Reinhard and Romero, Pedro and Mackensen, Andreas (2004) High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma. Cancer research 64 (17), pp. 6319-26.

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Abstract

Tumor-reactive T cells play an important role in cancer immunosurveillance. Applying the multimer technology, we report here an unexpected high frequency of Melan-A-specific CTLs in a melanoma patient with progressive lymph node metastases, consisting of 18 and 12.8% of total peripheral blood and tumor-infiltrating CD8+ T cells, respectively. Melan-A-specific CTLs revealed a high cytolytic ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15342421PubMed ID
10.1158/0008-5472.CAN-04-1341DOI
Classification:
NotationType
Antigens, NeoplasmMESH
Cysteine Endopeptidases/immunologyMESH
HLA-A2 Antigen/immunologyMESH
HumansMESH
Lymph Nodes/pathologyMESH
MaleMESH
Melanoma/immunologyMESH
Middle AgedMESH
Multienzyme Complexes/immunologyMESH
MutationMESH
Neoplasm Proteins/immunologyMESH
Proteasome Endopeptidase ComplexMESH
T-Lymphocytes, Cytotoxic/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:32
Last Modified:20 Apr 2010 05:32
Item ID:14436
Owner Only: item control page
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