Gebhard, Claudia and Schwarzfischer, Lucia and Pham, Thu Hang and Andreesen, Reinhard and Mackensen, Andreas and Rehli, Michael (2006) Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR. Nucleic acids research 34 (11), e82.
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Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. We have developed a novel technique for detecting CpG-methylated DNA termed methyl-binding (MB)-PCR. This technique utilizes a recombinant protein with high affinity for CpG-methylated DNA that is coated onto the walls of a PCR vessel and selectively ...
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|Institutions:||Medicine > Abteilung für Hämatologie und Internistische Onkologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||20 Apr 2010 09:38|
|Last Modified:||20 Apr 2010 09:38|