Jakse, G. and Hofstädter, Ferdinand (1983) Mechanisms of action of intravesical treatment. Effect on the ABH surface antigens of urothelial cells. Cancer chemotherapy and pharmacology = CCP 11, Suppl. 1, pp. 74-78.
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Blood group isoantigens can be demonstrated immune-histologically on normal urothelium of the urinaty bladder by means of the specific red cell adherence test. In preneoplastic and reactive changes of the urothelium and in dysplasia and carcinoma in situ, there is a loss of these antigens. Ultrastructural investigations of carcinoma in situ demonstrate a loss of normal membrane structures such as tight junctions,
desmosomes, and glycocalyx. Of 18 patients with carcinoma in
situ of the urinary bladder, 12 achieved tumor remission after
topical chemotherapy with doxorubicin hydrochloride. A
recurrence of blood group isoantigens was demonstrated in
patients who achieved tumor remission. The antigenicity
reappears before complete normalization of the urothelium.
Ultrastructural investigations demonstrated normalization of
cellular membrane structures in the respective biopsies. According to these findings and the current literature, the mechanisms of action of doxorubicin hydrochIoride in carcinoma in situ may be due to retardation of cell cycle, cell loss by desquamation, cell death, and decrease of growth fraction.
|Institutions:||Medicine > Lehrstuhl für Pathologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||26 May 2010 07:42|
|Last Modified:||26 May 2010 07:42|