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The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras oncogene

Le-Ruppert, K. and Masters, J. R. and Knuechel, R. and Seegers, S. and Tainsky, M. A. and Hofstaedter, Ferdinand and Buettner, R. (1992) The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras oncogene. International Journal of Cancer 51 (4), pp. 646-651.

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Abstract

Combination of chemotherapeutic drugs with agents that induce cell differentiation is a possible means of improving cancer chemotherapy. To explore this approach we used 4 cell lines established from the human teratocarcinoma-derived cell line PA-1; 2 retinoic acid (RA)-sensitive lines compared to 2 RA-resistant lines transformed by an activated N-ras oncogene. Equal numbers of colony-forming ...

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Item Type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
1376303PubMed ID
Classification:
NotationType
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Bleomycin/pharmacologyMESH
Cell Line, Transformed/drug effectsMESH
Cisplatin/pharmacologyMESH
Drug InteractionsMESH
Drug Screening Assays, AntitumorMESH
Etoposide/pharmacologyMESH
FemaleMESH
Fibronectins/analysisMESH
Genes, rasMESH
HumansMESH
Ovarian Neoplasms/geneticsMESH
Teratoma/geneticsMESH
TransfectionMESH
Tretinoin/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:09 Jun 2010 14:53
Last Modified:09 Jun 2010 14:53
Item ID:15254
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