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Laser microdissection and microsatellite analyses of breast cancer reveal a high degree of tumor heterogeneity

Wild, P. and Knuechel, R. and Dietmaier, W. and Hofstaedter, Ferdinand and Hartmann, A. (2000) Laser microdissection and microsatellite analyses of breast cancer reveal a high degree of tumor heterogeneity. Pathobiology: journal of immunopathology, molecular and cellular biology 68 (4-5), pp. 180-190.

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Abstract

Carcinomas with productive fibrosis are the most common forms of breast cancer. Analysis of tumor-specific genomic alterations can be compromised by the presence of normal cells, demanding microdissection of small tumor areas to detect loss of heterozygosity (LOH) and microsatellite instability (MSI). The aim of this study was to evaluate the importance of precise laser microdissection for ...

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Item Type:Article
Date:2000
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11279344PubMed ID
Classification:
NotationType
AdultMESH
Breast Neoplasms/pathologyMESH
Carcinoma, Ductal, Breast/pathologyMESH
Cell Separation/methodsMESH
Chromosomes, Human, Pair 17/geneticsMESH
Dissection/methodsMESH
FemaleMESH
Genetic HeterogeneityMESH
HumansMESH
LasersMESH
Loss of HeterozygosityMESH
Microsatellite Repeats/geneticsMESH
Middle AgedMESH
Predictive Value of TestsMESH
Prospective StudiesMESH
Trinucleotide Repeat Expansion/geneticsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Jun 2010 08:06
Last Modified:17 Jun 2010 08:06
Item ID:15369
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