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Detection of microsatellite instability by real time PCR and hybridization probe melting point analysis

Dietmaier, W. and Hofstädter, Ferdinand (2001) Detection of microsatellite instability by real time PCR and hybridization probe melting point analysis. Laboratory investigation 81 (10), pp. 1453-1456.

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Abstract

Microsatellite alterations can be found in a number of tumors. There are two types of alterations: loss of heterozygosity (LOH), which can be detected in the majority of colorectal cancers (CRC), and microsatellite instability (MSI). MSI occurs in about 15% of CRC with a mutator phenotype and are the hallmark of hereditary nonpolyposis colorectal cancers (HNPCC). Furthermore, MSI can also be ...

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Item Type:Article
Date:2001
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11598157PubMed ID
Classification:
NotationType
AnimalsMESH
HumansMESH
Microsatellite RepeatsMESH
MutationMESH
Nucleic Acid HybridizationMESH
Polymerase Chain Reaction/methodsMESH
Time FactorsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:54
Last Modified:18 Jun 2010 08:54
Item ID:15399
Owner Only: item control page
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