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Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern

Hafner, Christian and López-Knowles, Elena and Luis, Nuno M. and Toll, Agustí and Baselga, Eulàlia and Fernández-Casado, Alex and Hernández, Silvia and Ribé, Adriana and Mentzel, Thomas and Stoehr, Robert and Hofstaedter, Ferdinand and Landthaler, Michael and Vogt, Thomas and Pujol, Ramòn M. and Hartmann, Arndt and Real, Francisco X. (2007) Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proceedings of the National Academy of Sciences of the United States of America: PNAS 104 (33), pp. 13450-13454.

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Abstract

Activating mutations of the p110 alpha subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors. However, their role in benign or preneoplastic conditions is unknown. Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic mutations in epidermal nevi (EN) or as somatic mutations in seborrheic keratoses (SK). FGFR3 ...

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Item Type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10471491PubMed ID
10.1073/pnas.0705218104DOI
Classification:
NotationType
1-Phosphatidylinositol 3-Kinase/antagonists & inhibitorsMESH
HumansMESH
Keratosis, Seborrheic/geneticsMESH
MutationMESH
Nevus/geneticsMESH
Receptor, Fibroblast Growth Factor, Type 3/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Deposited On:18 Jun 2010 08:30
Last Modified:18 Jun 2010 08:30
Item ID:15420
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