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Activation of cytotoxic T lymphocytes requires at least two spleen cell-derived helper factors besides interleukin 2

Falk, Werner and Männel, D.N. and Dröge, W. (1983) Activation of cytotoxic T lymphocytes requires at least two spleen cell-derived helper factors besides interleukin 2. Journal of immunology (Baltimore, Md. : 1950) 130 (5), pp. 2214-2218.

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Abstract

The dependency of induction of T cell cytotoxicity on lymphokines was studied. 1 X 10(5) nylon wool-purified thymic lymphocytes or 10(4) spleen cells were cultured with TNP-haptenated syngeneic UV-irradiated spleen cells in the presence of a variety of lymphokine preparations. Concanavalin A-induced spleen cell supernatants mediated strong cytotoxic responses in this system. Three other ...

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Item Type:Article
Date:1983
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
6220085PubMed ID
Classification:
NotationType
AbsorptionMESH
AnimalsMESH
Concanavalin A/physiologyMESH
Cytotoxicity, ImmunologicMESH
Hydrogen-Ion ConcentrationMESH
Interleukin-2/physiologyMESH
Lymphocyte ActivationMESH
LymphokinesMESH
MiceMESH
Mice, Inbred C3HMESH
Mice, Inbred DBAMESH
Spleen/immunologyMESH
T-Lymphocytes, Cytotoxic/metabolismMESH
T-Lymphocytes, Helper-Inducer/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 05:05
Last Modified:13 Mar 2014 13:54
Item ID:15971
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