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Priming and triggering of tumoricidal and schistosomulicidal macrophages by two sequential lymphokine signals: interferon-gamma and macrophage cytotoxicity inducing factor 2

Krammer, P.H. and Kubelka, C.F. and Falk, Werner and Ruppel, A. (1985) Priming and triggering of tumoricidal and schistosomulicidal macrophages by two sequential lymphokine signals: interferon-gamma and macrophage cytotoxicity inducing factor 2. Journal of immunology (Baltimore, Md. : 1950) 135 (5), pp. 3258-3263.

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Abstract

We describe a new lymphokine activity, macrophage cytotoxicity inducing factor 2 (MCIF2), in the T cell mitogen-induced supernatant of a murine T cell clone in long-term culture. MCIF2 has the following properties: it elutes from a Sephadex G-100 column in three m.w. forms (10, 34, and 100 KD); it is acid labile (pH 2 to 4) and heat sensitive (80 min at 56 degrees C); it is not constitutively ...

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Item Type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3930600PubMed ID
Classification:
NotationType
AnimalsMESH
Chemistry, PhysicalMESH
Clone Cells/metabolismMESH
Cytotoxicity, ImmunologicMESH
Drug SynergismMESH
FemaleMESH
Interferon-gamma/pharmacologyMESH
Lymphokines/physiologyMESH
Macrophage ActivationMESH
Macrophage-Activating FactorsMESH
MaleMESH
Mast-Cell Sarcoma/immunologyMESH
MiceMESH
Mice, Inbred C57BLMESH
Mice, Inbred DBAMESH
Physicochemical PhenomenaMESH
Recombinant ProteinsMESH
Schistosomiasis mansoniMESH
T-Lymphocytes/metabolismMESH
Time FactorsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 05:12
Last Modified:13 Mar 2014 13:54
Item ID:15977
Owner Only: item control page

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