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Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni

Esparza, I. and Männel, Daniela N. and Ruppel, A. and Falk, Werner and Krammer, P.H. (1987) Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. The Journal of experimental medicine 166 (2), pp. 589-594.

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Abstract

Macrophages play a crucial role in the defense against tumors and parasites. Activation of tumoricidal and microbicidal effector mechanisms requires stimulation of macrophages with macrophage-activating factors (MAF). One such MAF is interferon gamma (IFN-gamma). In some assays, substantial activity of IFN-gamma on murine macrophages, however, is only observed in synergy with lipopolysaccharide ...

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Item Type:Article
Date:1987
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
3080522PubMed ID
Classification:
NotationType
Cells, CulturedMESH
Glycoproteins/pharmacologyMESH
Interferon-gamma/pharmacologyMESH
Lymphotoxin-alpha/pharmacologyMESH
Macrophage ActivationMESH
Neoplasms, Experimental/immunologyMESH
Recombinant Proteins/pharmacologyMESH
Schistosoma mansoni/immunologyMESH
Tumor Necrosis Factor-alphaMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 09:21
Last Modified:13 Mar 2014 13:54
Item ID:15986
Owner Only: item control page
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