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Endotoxic activities of tumor necrosis factor independent of IL1 secretion by macrophages/monocytes

Männel, D.N. and Falk, Werner and Northoff, H. (1987) Endotoxic activities of tumor necrosis factor independent of IL1 secretion by macrophages/monocytes. Lymphokine research 6 (3), pp. 151-159.

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Abstract

Recombinant tumor necrosis factor (TNF) had hypothermic activity in vivo. Intravenous injection of TNF resulted in a hypothermic reaction of mice within 3 to 6 hours. This reaction was not the result of interleukin 1 (IL1) release from macrophages/monocytes. Peritoneal exudate cell cultures from endotoxin low responder mice or human peripheral mononuclear leukocyte cultures did not generate IL1 ...

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Item Type:Article
Date:1987
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3114568PubMed ID
Classification:
NotationType
AnimalsMESH
Cells, CulturedMESH
EndotoxinsMESH
Glycoproteins/toxicityMESH
HumansMESH
Hypothermia/chemically inducedMESH
Interferon-gamma/pharmacologyMESH
Interleukin-1/secretionMESH
Macrophages/physiologyMESH
MaleMESH
MiceMESH
Mice, Inbred C3HMESH
Monocytes/physiologyMESH
Recombinant Proteins/toxicityMESH
Tumor Necrosis Factor-alphaMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 09:19
Last Modified:13 Mar 2014 13:54
Item ID:15989
Owner Only: item control page
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