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Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2

Debatin, K.M. and Woodroofe, C. and Lahm, H. and Fischer, J. and Falk, Werner and Brandeis, W.E. and Krammer, P.H. (1989) Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 3 (8), pp. 566-571.

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Abstract

Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...

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Item Type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
2787451PubMed ID
Classification:
NotationType
AdolescentMESH
ChildMESH
Child, PreschoolMESH
FemaleMESH
HumansMESH
Interleukin-2/physiologyMESH
Leukemia-Lymphoma, Adult T-Cell/pathologyMESH
Lymphocyte ActivationMESH
Lymphoma, Non-Hodgkin/pathologyMESH
MaleMESH
PhenotypeMESH
Receptors, Interleukin-2/analysisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:22 Jul 2010 05:00
Last Modified:13 Mar 2014 13:54
Item ID:15995
Owner Only: item control page
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