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Downregulation of methylthioadenosine phosphorylase promotes progression of hepatocellular carcinoma via accumulation of 5´-deoxy-5´-methylthioadenosine

URN to cite this document: urn:nbn:de:bvb:355-epub-160462

Kirovski, Georgi (2010) Downregulation of methylthioadenosine phosphorylase promotes progression of hepatocellular carcinoma via accumulation of 5´-deoxy-5´-methylthioadenosine. PhD, Universität Regensburg

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Abstract (English)

Recently, it has been shown that downregulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhanced cell proliferation and resistance against cytokines. The aim of this work was to investigate the molecular mechanism underlying this tumor-promoting effect and to expand previous analysis to a large series of human HCC tissues. Liquid chromatography tandem ...

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Translation of the abstract (German)

Einführung: Das hepatozelluläre Karzinom (HCC) nimmt weltweit den dritten Platz unter den krebsbedingten Todesursachen ein. Die häufigsten Risikofaktoren für die HCC Entstehung sind chronische Hepatitis B und C Infektion sowie chronischer Alkoholabusus, die zu einer Leberzirrhose führen. Weniger bekannt ist jedoch die molekulare Pathogenese des HCC. Viele genomische Veränderungen im HCC Verlauf ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:15 November 2010
Referee:Prof. Dr. Claus Hellerbrand
Date of exam:27 July 2010
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Research groups and research centres:Not selected
Keywords:hepatocellular carcinoma, methylthioadenosine phosphorylase, accumulation of 5´-deoxy-5´-methythioadenosine
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Nov 2010 10:05
Last Modified:13 Mar 2014 14:09
Item ID:16046
Owner Only: item control page
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