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Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis

Rupprecht, M. and Rupprecht, R. and Kornhuber, J. and Wodarz, Norbert and Koch, H. U. and Riederer, P. and Hornstein, O. P. (1991) Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis. Dermatologica 183 (2), pp. 100-105.

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Abstract

The number and affinity of glucocorticoid binding sites in peripheral mononuclear leukocytes of patients with atopic dermatitis (AD) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment. Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors (GR) per cell than the control group (n = 22), while the GR affinity did ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
1660414PubMed ID
Classification:
NotationType
3',5'-Cyclic-AMP Phosphodiesterases/physiologyMESH
AdolescentMESH
AdultMESH
Contraceptives, Oral/pharmacologyMESH
Cyclic AMP/physiologyMESH
Dermatitis, Atopic/immunologyMESH
Dexamethasone/therapeutic useMESH
FemaleMESH
HumansMESH
Hydrocortisone/bloodMESH
Leukocytes, Mononuclear/chemistryMESH
MaleMESH
Methylprednisolone/therapeutic useMESH
Receptors, Glucocorticoid/analysisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:27 Aug 2010 12:12
Last Modified:13 Mar 2014 14:04
Item ID:16341
Owner Only: item control page
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