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The effect of kirromycin on the metal ion coordination in complexes of elongation factor Tu from Bacillus stearothermophilus as inferred from the ¹⁷O-⁵⁵Mn superhyperfine interaction

Kalbitzer, Hans Robert and Wittinghofer, A. (1991) The effect of kirromycin on the metal ion coordination in complexes of elongation factor Tu from Bacillus stearothermophilus as inferred from the ¹⁷O-⁵⁵Mn superhyperfine interaction. Biochimica et biophysica acta 1078 (2), pp. 133-138.

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Abstract

The binding of the antibiotic kirromycin to elongation factor Tu (EF-Tu) leads to a severe line broadening of the Q-band manganese EPR lines of EF-Tu.Mn, EF-Tu.Mn.GDP, as well as EF-Tu.Mn.GDP.Pi indicating that the coordination sphere of the metal ion is changed by this interaction. The number of coordinated water molecules was determined from the 17O-55Mn superhyperfine coupling observable in ...

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Item Type:Article
Date:1991
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
1648403PubMed ID
Classification:
NotationType
Anti-Bacterial Agents/pharmacologyMESH
Electron Spin Resonance SpectroscopyMESH
Geobacillus stearothermophilus/metabolismMESH
Manganese/chemistryMESH
Metals/chemistryMESH
Oxygen/chemistryMESH
Peptide Elongation Factor Tu/metabolismMESH
Pyridones/pharmacologyMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:07 Sep 2010 06:23
Last Modified:07 Sep 2010 06:23
Item ID:16456
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