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Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

Schweins, T. and Geyer, M. and Scheffzek, K. and Warshel, A. and Kalbitzer, Hans Robert and Wittinghofer, A. (1995) Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins. Nature structural biology 2 (1), pp. 36-44.

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Abstract

Despite many advances in understanding the structure and function of GTP-binding proteins the mechanism by which these molecules switch from the GTP-bound on-state to the GDP-bound off-state is still poorly understood. Theoretical studies suggest that the activation of the nucleophilic water which hydrolyzes GTP needs a general base. Such a base could not be located in any of the many GTP-binding ...

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Item Type:Article
Date:1995
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
7719851PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Binding SitesMESH
CatalysisMESH
Cell Transformation, Neoplastic/metabolismMESH
Computer SimulationMESH
Crystallography, X-RayMESH
GTP-Binding Proteins/metabolismMESH
GTPase-Activating ProteinsMESH
GlutamineMESH
Guanosine Triphosphate/metabolismMESH
HydrolysisMESH
InsectsMESH
KineticsMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Mutagenesis, Site-DirectedMESH
Protein BindingMESH
Protein ConformationMESH
Proteins/physiologyMESH
Proto-Oncogene Proteins p21(ras)/metabolismMESH
Recombinant Fusion Proteins/metabolismMESH
Structure-Activity RelationshipMESH
ThermodynamicsMESH
Water/metabolismMESH
ras GTPase-Activating ProteinsMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:08 Sep 2010 08:08
Last Modified:08 Sep 2010 08:08
Item ID:16510
Owner Only: item control page
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