Nordhoff, A. and Tziatzios, C. and van den Broek, J. A. and Schott, M. K. and Kalbitzer, Hans Robert and Becker, K. and Schubert, D. and Schirmer, R. H. (1997) Denaturation and reactivation of dimeric human glutathione reductase: an assay for folding inhibitors. European journal of biochemistry (=the FEBS journal) 245 (2), pp. 273-282.
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Human glutathione reductase (GR; which catalyzes the reaction NADPH + GSSG + H+ --> 2 GSH + NADP+) is an obligatory FAD-containing homodimer of known geometry. Native human GR, a potential target of antimalarial and cytostatic agents, cannot be dissociated by dilution or by means of subunit-interface mimetics, similarly to well-studied viral dimeric proteins. However, ab initio folding and/or ...
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|Institutions:||Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer|
|Dewey Decimal Classification:||500 Science > 570 Life sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||13 Sep 2010 08:16|
|Last modified:||13 Sep 2010 08:16|