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Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy

Geyer, Matthias and Wilde, Christian and Selzer, Jörg and Aktories, Klaus and Kalbitzer, Hans Robert (2003) Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy. Biochemistry 42 (41), pp. 11951-11959.

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Abstract

The lethal toxin (LT) from Clostridium sordellii, which belongs to the family of large clostridial cytotoxins, acts as a monoglucosyltransferase for the Rho subfamily GTPase Rac and also modifies Ras. In the present study we investigated structural changes of H-Ras in its di- and triphosphate form that occur upon glucosylation of the effector domain amino acid threonine-35 by LT. (31)P NMR ...

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Item Type:Article
Date:2003
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
14556626PubMed ID
10.1021/bi034529vDOI
Classification:
NotationType
Bacterial Toxins/chemistryMESH
Binding SitesMESH
Clostridium/chemistryMESH
Gluconates/chemistryMESH
Glucose/metabolismMESH
Guanosine Diphosphate/metabolismMESH
Guanylyl Imidodiphosphate/chemistryMESH
Hexoses/metabolismMESH
HumansMESH
KineticsMESH
Magnetic Resonance Spectroscopy/methodsMESH
Phosphorus Isotopes/metabolismMESH
Protein ConformationMESH
Protein DenaturationMESH
Recombinant Proteins/metabolismMESH
Signal TransductionMESH
Substrate SpecificityMESH
Threonine/chemistryMESH
Urea/chemistryMESH
ras Guanine Nucleotide Exchange Factors/metabolismMESH
ras Proteins/metabolismMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:16 Sep 2010 09:14
Last Modified:16 Sep 2010 09:14
Item ID:16602
Owner Only: item control page
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