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Zusammenfassung
From the lipophilic ext. of Verbesina turbacensis (-)-bornyl caffeate (I), (-)-bornyl ferulate (II), (-)-bornyl p-coumarate (III), and (-)-bornyl cis-4-hydroxy-cinnamate were isolated. The structures were established from spectral (UV, MS, 1H and 13C NMR) and polarimetric data. Compds. I-III were studied for their antiinflammatory activity using the 5-lipoxygenase assay. It could be shown that ...
Zusammenfassung
From the lipophilic ext. of Verbesina turbacensis (-)-bornyl caffeate (I), (-)-bornyl ferulate (II), (-)-bornyl p-coumarate (III), and (-)-bornyl cis-4-hydroxy-cinnamate were isolated. The structures were established from spectral (UV, MS, 1H and 13C NMR) and polarimetric data. Compds. I-III were studied for their antiinflammatory activity using the 5-lipoxygenase assay. It could be shown that the strong influence on the 5-lipoxygenase pathway is due to their antioxidative properties which was proven in an in vitro (TLC anal. with DPPH reagent) and an ex vivo (inhibition of chemiluminescence in human polymorphonuclear granulocytes (PMNs)) test system. Thus, the inhibitory activity on 5-lipoxygenase and on the prodn. of reactive oxygen species in human PMNs contributes to the reported antiinflammatory activity for V. turbacensis.
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