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Bioactive natural products from the Popoluca Indian medicinal plant Mosquitoxylum jamaicense (Anacardiaceae)

Leonti, Marco and Heilmann, Jörg and Heinrich, Michael and Sticher, Otto (2004) Bioactive natural products from the Popoluca Indian medicinal plant Mosquitoxylum jamaicense (Anacardiaceae). Revista latinoamericana de química 32 (3), pp. 87-94.

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Abstract

In the traditional medicine of the Sierra Popoluca (Veracruz, Mexico) a decoction of the bark of Mosquitoxylum jamaicense (Anacardiaceae) is used to treat menstrual problems and gonorrhea. Both, the non-polar as well as the polar ext. showed significant cytotoxicity against KB cells in vitro. The fractionation and isolation process resulted in non-cytotoxic trans-anacardic acid, a new but probably not genuine compd. Furthermore, we report for the first time on the cytotoxicity of the isolated and previously known compds. dammarenediol, 2,3-trans-3-methoxyfustin and sulfuretin.

Item Type:

Article

Additional information (public):

CAN 142:403366 1-1 Pharmacology 38681-23-1P Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than 2,3-trans-3-methoxyfustin in KB cell line); 83-46-5P (beta -Sitosterol); 99-24-1P (Methyl gallate); 480-18-2P ((+)-Taxifolin); 514-47-6P (Euphol); 444573-46-0P Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than Me gallate in KB cell line); 14351-29-2P (Dammarenediol II) Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than dammarenediol in KB cell line); 487-52-5P (Butein) Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than dammarenediol, 2,3-trans-3-methoxyfustin, Me gallate, sulfuretin in KB cell line); 120-05-8P (Sulfuretin) Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than sulfuretin in KB cell line)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)

Identification Number:

Value	Type
2005:243324	Other

Keywords:

Anacardiaceae Cytotoxicity Mass spectra (butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than dammarenediol, 2,3-trans-3-methoxyfustin, Me gallate, sulfuretin in KB cell line) Natural products Role: NPO (Natural product occurrence), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (butein from mosquitoxylum jamaicense ext. showed strongest cytot NMR (carbon-13 butein from mosquitoxylum jamaicense ext. showed strongest cytotoxic activity than dammarenediol, 2,3-trans-3-methoxyfustin, Me gallate, sulfuretin in KB cell line) mosquitoxylum jamaicense ext cytotoxicity

Subjects:

500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Owner:

Prof. Dr. Joerg Heilmann

Deposited On:

18 Oct 2010 14:40

Last Modified: