Vlachy, N. and Touraud, D. and Heilmann, Jörg and Kunz, W. (2009) Determining the cytotoxicity of catanionic surfactant mixtures on HeLa cells. Colloids and surfaces: B, Biointerfaces 70 (2), pp. 278-280.
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The cytotoxicity of commonly used synthetic surfactants and catanionic mixts. of those was evaluated using MTT on HeLa cells. The 50% inhibition concn. (IC50) for MTT redn. was calcd. The effect on chain length increase and inclusion of polyoxyethylene groups on the toxicity was tested on single surfactant systems. A general trend of increasing toxicity with increasing chain length and the presence of polyoxyethylene groups was obsd. The measured IC50 values of catanionic systems lie between those of participating surfactants. The increase in toxicity as the cationic surfactant is added to the anionic one is however not linear. A steep decrease of the IC50 values (and therefore increase in the toxic properties) is obsd. immediately already at low concns. of the cationic surfactants. This behavior is analogous to the enzyme activity in catanionic microemulsions.
|Additional information (public):||CAN 150:532298 4-1 Toxicology 151-21-3 (SDS); 629-25-4 (Sodium dodecanoate); 1984-06-1 (Sodium octanoate); 33939-64-9 (Akypo Soft 45NV); 336791-12-9 (Texapon SPN 70) Role: ADV (Adverse effect, including toxicity), BIOL (Biological study) (cytotoxicity of ionic surfactant mixts. on HeLa cells)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)|
|Keywords:||Cytotoxicity HeLa cell Human (cytotoxicity of ionic surfactant mixts. on HeLa cells) Surfactants (ionic cytotoxicity of ionic surfactant mixts. on HeLa cells) ionic surfactant cytotoxicity HeLa cell line|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Dr. Joerg Heilmann|
|Deposited On:||18 Oct 2010 15:54|
|Last Modified:||18 Oct 2010 15:54|
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