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3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat

Hartmann, R. W. and Schönenberger, Helmut and Wrobel, K. H. (1982) 3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat. Journal of cancer research and clinical oncology 103 (3), pp. 241-254.

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Abstract

The mechanism of the antitumor activity of 3,4-bis(3'-hydroxyphenyl)hexane (I) [71953-72-5] was studied in rats with DMBA-induced mammary tumors. Changes in the tumor enzyme levels and histol. characteristics during I treatment were examd. and compared with those induced by hexestrol, tamoxifen, and ovariectomy. It was not possible to conclude whether the estrogenic or antiestrogenic activity of I was responsible for its antitumor activity.


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Item Type:Article
Date:1982
Additional Information (public):CAN 97:138268 1-6 Pharmacology 71953-72-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, antiestrogenic and estrogenic activity in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1982:538268Other
Keywords:Neoplasm inhibitors (bis(hydroxyphenyl)hexane as, mechanism of, antiestrogenic and estrogenic activity in relation to) Estrogens Role: BIOL (Biological study) (neoplasm inhibition by bis(hydroxyphenyl)hexane in relation to) hydroxyphenylhexane antitumor mechanism
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:12 Nov 2010 09:28
Last Modified:12 Nov 2010 09:28
Item ID:17633
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