Deutsch
Ball, Hartwig and Schneider, Martin R. and Schönenberger, Helmut (1984) 1-(Dimethylamino)-2,3,3-triphenylprop-1-enes: synthesis and affinity with estradiol receptor. Archiv der Pharmazie 317 (6), pp. 565-571.
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Abstract
Title compds. (I) (R, R1, R2 = H, MeO; E-2 isomer mixts. where applicable) were prepd. from 4-RC6H4COCH2C6H4R1-4 (R, R1 = H, H; MeO, H; H, MeO; MeO, MeO) via Mannich reaction, Grignard reaction with 4-R2C6H4Br, and dehydration, and were <1/10 as effective as estradiol receptors as (4-HOC6H4)2C:CEtPh.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Additional information (public): | CAN 101:72346 25-4 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 120-44-5; 451-40-1; 1023-17-2; 24845-40-7 Role: RCT (Reactant), RACT (Reactant or reagent) (Mannich reaction of); 82333-70-8 Role: RCT (Reactant), RACT (Reactant or reagent) (basic hydrolysis of); 1892-36-0P; 22563-99-1P; 91221-28-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and Grignard reaction with bromobenzene); 29149-14-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and Grignard reaction with bromobenzenes); 91221-46-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity as estradiol receptor); 7464-67-7P; 91221-29-3P; 91221-30-6P; 91221-31-7P; 91221-32-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and dehydration of); 91221-40-8P; 91221-41-9P; 91221-42-0P; 91221-43-1P; 91221-44-2P; 91221-45-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estradiol receptor inactivity of); 91221-34-0P; 91221-35-1P; 91221-36-2P; 91221-37-3P; 91221-38-4P; 91221-39-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of); 1938-35-8P; 25287-79-0P; 29149-21-1P; 91221-27-1P; 91221-33-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 50-28-2P Role: PREP (Preparation) (receptors for, inactivity of aminotriarylpropylene deriv. as) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
| ||||
| Keywords: | aminoarylpropylene estradiol receptor inactivity propylene aminoaryl estradiol | ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Owner: | Petra Gürster | ||||
| Deposited On: | 12 Nov 2010 10:03 | ||||
| Last Modified: | 12 Nov 2010 10:03 | ||||
| Item ID: | 17645 |
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