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1-(Dimethylamino)-2,3,3-triphenylprop-1-enes: synthesis and affinity with estradiol receptor

Ball, Hartwig and Schneider, Martin R. and Schönenberger, Helmut (1984) 1-(Dimethylamino)-2,3,3-triphenylprop-1-enes: synthesis and affinity with estradiol receptor. Archiv der Pharmazie 317 (6), pp. 565-571.

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Abstract

Title compds. (I) (R, R1, R2 = H, MeO; E-2 isomer mixts. where applicable) were prepd. from 4-RC6H4COCH2C6H4R1-4 (R, R1 = H, H; MeO, H; H, MeO; MeO, MeO) via Mannich reaction, Grignard reaction with 4-R2C6H4Br, and dehydration, and were <1/10 as effective as estradiol receptors as ...

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Item Type:Article
Date:1984
Additional information (public):CAN 101:72346 25-4 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 120-44-5; 451-40-1; 1023-17-2; 24845-40-7 Role: RCT (Reactant), RACT (Reactant or reagent) (Mannich reaction of); 82333-70-8 Role: RCT (Reactant), RACT (Reactant or reagent) (basic hydrolysis of); 1892-36-0P; 22563-99-1P; 91221-28-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and Grignard reaction with bromobenzene); 29149-14-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and Grignard reaction with bromobenzenes); 91221-46-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity as estradiol receptor); 7464-67-7P; 91221-29-3P; 91221-30-6P; 91221-31-7P; 91221-32-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and dehydration of); 91221-40-8P; 91221-41-9P; 91221-42-0P; 91221-43-1P; 91221-44-2P; 91221-45-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estradiol receptor inactivity of); 91221-34-0P; 91221-35-1P; 91221-36-2P; 91221-37-3P; 91221-38-4P; 91221-39-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of); 1938-35-8P; 25287-79-0P; 29149-21-1P; 91221-27-1P; 91221-33-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 50-28-2P Role: PREP (Preparation) (receptors for, inactivity of aminotriarylpropylene deriv. as)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1984:472346Other
Keywords:aminoarylpropylene estradiol receptor inactivity propylene aminoaryl estradiol
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:03
Last Modified:12 Nov 2010 09:03
Item ID:17645
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