Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthard (1984) cis-Dichloro[bis(oligopeptide ester)]platinum(II) complexes, study on the detection of antitumor activity with bacteriological test systems. Archiv der Pharmazie 317 (9), pp. 760-767.
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Sixteen title compds., PtA2Cl2 (A = peptide ester groups), and 10 known antitumor compds. were compared in 3 bacteriol. tests: filament induction in Escherichia coli B, growth inhibition of DNA polymerase-deficient E. coli p 3478 pol A-, and prophage induction in E. coli K12 (l). The compds. were also tested for inhibition of ADJ/PC6 plasmacytoma growth in vitro. Only the prophage induction test correlated with the neoplasm-inhibitory activity, suggesting it as a screening method for detecting antineoplastic Pt complexes.
|Additional information (public):||CAN 101:183332 1-1 Pharmacology 56-87-1D; 7440-06-4D; 14096-51-6; 14913-33-8; 15663-27-1; 85200-51-7; 92785-53-0; 92785-54-1; 92785-55-2; 92785-56-3; 92785-57-4; 92785-58-5; 92785-59-6; 92785-60-9; 92785-61-0; 92785-62-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, Escherichia coli systems for detection of); 50-07-7; 50-18-0; 50-76-0; 51-21-8; 55-86-7; 57-22-7; 59-05-2; 127-07-1; 865-21-4; 9015-68-3 Role: BIOL (Biological study) (Escherichia coli systems response to and neoplasm inhibition by, platinum complexes screening for antitumor activity in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Escherichia coli (platinum complexes screening for neoplasm-inhibitory activity in) Neoplasm inhibitors (platinum-bis(oligopeptide ester) complexes as, screening of, in Escherichia coli) platinum complex antitumor screening Escherichia|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:56|
|Last Modified:||12 Nov 2010 08:56|