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Acetoxy-substituted 1,1,2-triphenylbut-1-enes with antiestrogenic and mammary tumor inhibiting properties

Schneider, Martin R. and Ball, Hartwig and Schönenberger, Helmut (1985) Acetoxy-substituted 1,1,2-triphenylbut-1-enes with antiestrogenic and mammary tumor inhibiting properties. Journal of medicinal chemistry 28 (12), pp. 1880-1885.

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Abstract

1,1,2-Triphenylbut-1-enes I (R, R1, and R2 are H, OAc) which are substituted with one p- and one m-acetoxy group in two different arom. rings, were synthesized. The (E) and (Z) isomers were isolated, and their identity was established by 1H NMR spectroscopy. Among the tested compds., (E)- and (Z)-1-(3-acetoxyphenyl)-1-(4-acetoxyphenyl)-2-phenylbut-1-enes [(E)-I and (Z)-I] and ...

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Item Type:Article
Date:1985
Additional information (public):CAN 103:195868 25-10 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 2398-37-0 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with deoxybenzoin deriv.); 75-03-6 Role: RCT (Reactant), RACT (Reactant or reagent) (alkylation by, of deoxybenzoin deriv.); 1023-17-2 Role: RCT (Reactant), RACT (Reactant or reagent) (alkylation of, by Et iodide); 13732-58-6; 98540-35-3; 98540-36-4; 98540-37-5 Role: RCT (Reactant), RACT (Reactant or reagent) (hydrolysis of, and O-acetylation of product from); 78423-10-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and Grignard reaction of, with bromoanisole); 98540-29-5P; 98540-30-8P; 98540-33-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 98540-27-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and dehydration of); 98540-28-4P; 98633-97-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of, and O-acetylation of product from); 98540-26-2P; 98540-31-9P; 98540-32-0P; 98540-34-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 108-24-7 Role: RCT (Reactant), RACT (Reactant or reagent) (O-acylation by, of bis(hydroxyphenyl)butenes)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1985:595868Other
Keywords:Neoplasm inhibitors (bis(acetoxyphenyl)phenylbutenes) Estrogens Role: USES (Uses) (inhibitors, bis(acetoxyphenyl)phenylbutenes as) styrylphenyl acetate prepn antitumor antiestrogenic styrylphenylacetate prepn
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:41
Last Modified:12 Nov 2010 08:41
Item ID:17653
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