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Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

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Abstract

Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most ...

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Item Type:Article
Date:1988
Additional information (public):GERMANY, WEST: Germany, Federal Republic of
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1988315108Other
Keywords:Animals *Antineoplastic Agents: PD, pharmacology Breast Neoplasms: PA, pathology Carcinoma, Ehrlich Tumor: PA, pathology Cell Line Drug Screening Assays, Antitumor Humans Leukemia P388: PA, pathology *Organoplatinum Compounds: TU, therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds)
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:19
Last Modified:12 Nov 2010 08:19
Item ID:17667
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