Browse:

The university is member of the Confederation of Open Access Repositories (COAR)

More information about Open Acces at open-acces.net

Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

Full text not available from this repository.

Abstract

Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.

Item Type:

Article

Additional information (public):

GERMANY, WEST: Germany, Federal Republic of

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1988315108	Other

Keywords:

Animals *Antineoplastic Agents: PD, pharmacology Breast Neoplasms: PA, pathology Carcinoma, Ehrlich Tumor: PA, pathology Cell Line Drug Screening Assays, Antitumor Humans Leukemia P388: PA, pathology *Organoplatinum Compounds: TU, therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds)

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 09:19