Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.
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Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.
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|Additional Information (public):||GERMANY, WEST: Germany, Federal Republic of|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Animals *Antineoplastic Agents: PD, pharmacology Breast Neoplasms: PA, pathology Carcinoma, Ehrlich Tumor: PA, pathology Cell Line Drug Screening Assays, Antitumor Humans Leukemia P388: PA, pathology *Organoplatinum Compounds: TU, therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:19|
|Last Modified:||12 Nov 2010 08:19|