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Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1991) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments. Archiv der Pharmazie 324 (3), pp. 153-160.

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Abstract

The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In expts. performed with asparaginase, L-aspartic acid-beta -hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.

Item Type:

Article

Additional information (public):

CAN 114:220909 1-6 Pharmacology 50-67-9 (5-Hydroxy-tryptamine); 60-23-1 (Cysteamine); 62-57-7 (2-Aminoisobutyric acid); 500-44-7 (Mimosine); 526-31-8; 1955-68-6; 2697-61-2 (Selenocystamine); 2792-72-5; 2799-07-7 (s-Trityl-L-cysteine); 2897-21-4 (DL-Selenocystine); 2936-69-8 (L-4-Thialysine); 4746-36-5 (DL-4-Azaleucine); 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 16748-73-5; 19461-04-2; 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 34985-37-0 ((S)-2-Methylbutylamine); 57734-57-3 (2-Pyrrolidinemethanamine); 77834-86-7; 80300-21-6; 125293-76-7; 125293-86-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, as excitatory amino acid antagonist); 50-44-2 (6-Mercapto-purine); 50-76-0 (Actinomycin D); 51-21-8 (5-Fluorouracil); 59-05-2 (Methotrexate); 127-07-1 (Hydroxyurea); 147-94-4 (Ara C); 148-82-3; 15663-27-1 (Cisplatin); 105856-26-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, excitatory amino acid antagonists effect on); 9015-68-3 (Asparaginase) Role: BIOL (Biological study) (antitumor activity with excitatory amino acid antagonists); 9028-02-8 (Aminoacyl-tRNA synthetase) Role: PROC (Process) (inhibition of, by excitatory amino acid inhibitors, antitumor activity in relation to)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1991:220909	Other

Keywords:

Neoplasm inhibitors (excitatory amino acid antagonists as) Amino acids Role: BIOL (Biological study) (excitatory, antagonists of, antitumor activity of, aminoacyl-tRNA synthetase targeting in) amino acid antagonist aminoacyl synthetase synthetase antitumor amino acid antagonist

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 08:13