Stereoisomeric dichloro[1-(hydroxyphenyl)-2-phenyl-1,2-ethanediamine]platinum(II) complexes. I. Synthesis

Abstract

erythro- And threo-PtLCl2 (L = 1-(R-substituted) (phenyl)-2-phenyl-1,2-ethanediamine (R = 2-, 3-, 4-OH)) were synthesized. The diastereoisomeric 1-(3-hydroxyphenyl)-2-phenyl-1,2-ethanediamines and threo-1-(2-hydroxyphenyl)-2-phenyl-1,2-ethanediamine were obtained by redn. of the 1,2-diazidoethanes. The configuration of threo-1,2-diazido-1-(2-methoxyphenyl)-2-phenylethane (I) was elucidated by x-ray anal. The redn. of the erythro-1,2-diaryl-1,2-diazidoethanes, substituted with a MeO group in o- or p-position, results in elimination reactions with formation of side products. The desired 1,2-diaryl-1,2-ethanediamines were finally synthesized via either an aziridine deriv. or by redn. of the resp. dioximes. The diamine ligands were converted to PtLC2. I is monoclinic, space group P21/n, a 1017.5(6), b 833.7(6), c 1448.6(2) pm, beta 98.53 Deg, Z = 4, Rw = 0.093.