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Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

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Abstract

2,6-Dichloro-4-hydroxybenzylamine (1) and its N-Me (2) and N-Et (3) derivs. were synthesized and tested for estrogen receptor affinity as well as for estrogenic activity. In contrast to their related highly active 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines (meso-4 - meso-6) none of the benzylamines showed hormonal activity. The coordination of the benzylamine 1 to platinum did not lead ...

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Item Type:Article
Date:1994
Additional information (public):CAN 122:95262 78-7 Inorganic Chemicals and Reactions 82772-93-8 (2,6-Dichloro-4-methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of (dichlorohydroxybenzyl)amine and its platinum complexes); 10025-99-7P (Dipotassium tetrachloroplatinate(2-); 14708-56-6P (Dipotassium tetraiodoplatinate(2-); 82772-94-9P; 82772-95-0P; 160522-39-4P (2,6-Dichloro-4-methoxybenzaldoxime); 160522-40-7P (2,6-Dichloro-4-methoxybenzylamine); 160522-41-8P ((2,6-Dichloro-4-methoxybenzyl)methylamine); 160522-42-9P ((2,6-Dichloro-4-methoxybenzyl)ethylamine) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (for prepn. of (dichlorohydroxybenzyl)amine and its platinum complexes); 160522-33-8P (2,6-Dichloro-4-hydroxybenzylamine); 160522-34-9P ((2,6-Dichloro-4-hydroxybenzyl)methylamine); 160522-35-0P ((2,6-Dichloro-4-hydroxybenzyl)ethylamine) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes); 160522-36-1P (cis-Dichlorobis(2,6-dichloro-4-methoxybenzylamine)platinum); 160522-37-2P (cis-Dichlorobis(2,6-dichloro-4-hydroxybenzylamine)platinum); 160522-38-3P (trans-Bis(2,6-dichloro-4-hydroxybenzylamine)diiodoplatinum) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1995:281327Other
Keywords:Estrogens Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its Estrogen receptors Role: PRP (Properties) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) Receptors Role: PRP (Properties) (estrogen, prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) estrogen activity dichlorohydroxybenzylamine platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:10 Nov 2010 12:04
Last Modified:12 Nov 2010 06:22
Item ID:17704
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