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Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes

Gust, Ronald und Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), S. 763-769.

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Zusammenfassung

2,6-Dichloro-4-hydroxybenzylamine (1) and its N-Me (2) and N-Et (3) derivs. were synthesized and tested for estrogen receptor affinity as well as for estrogenic activity. In contrast to their related highly active 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines (meso-4 - meso-6) none of the benzylamines showed hormonal activity. The coordination of the benzylamine 1 to platinum did not lead ...

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Dokumentenart:Artikel
Datum:1994
Zusätzliche Informationen (Öffentlich):CAN 122:95262 78-7 Inorganic Chemicals and Reactions 82772-93-8 (2,6-Dichloro-4-methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (for prepn. of (dichlorohydroxybenzyl)amine and its platinum complexes); 10025-99-7P (Dipotassium tetrachloroplatinate(2-); 14708-56-6P (Dipotassium tetraiodoplatinate(2-); 82772-94-9P; 82772-95-0P; 160522-39-4P (2,6-Dichloro-4-methoxybenzaldoxime); 160522-40-7P (2,6-Dichloro-4-methoxybenzylamine); 160522-41-8P ((2,6-Dichloro-4-methoxybenzyl)methylamine); 160522-42-9P ((2,6-Dichloro-4-methoxybenzyl)ethylamine) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (for prepn. of (dichlorohydroxybenzyl)amine and its platinum complexes); 160522-33-8P (2,6-Dichloro-4-hydroxybenzylamine); 160522-34-9P ((2,6-Dichloro-4-hydroxybenzyl)methylamine); 160522-35-0P ((2,6-Dichloro-4-hydroxybenzyl)ethylamine) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes); 160522-36-1P (cis-Dichlorobis(2,6-dichloro-4-methoxybenzylamine)platinum); 160522-37-2P (cis-Dichlorobis(2,6-dichloro-4-hydroxybenzylamine)platinum); 160522-38-3P (trans-Bis(2,6-dichloro-4-hydroxybenzylamine)diiodoplatinum) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1995:281327Andere
Stichwörter / Keywords:Estrogens Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its Estrogen receptors Role: PRP (Properties) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) Receptors Role: PRP (Properties) (estrogen, prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) estrogen activity dichlorohydroxybenzylamine platinum complex
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:10 Nov 2010 12:04
Zuletzt geändert:12 Nov 2010 06:22
Dokumenten-ID:17704
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