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Zusammenfassung
A review. Platinum complexes with carrier ligands were synthesized to overcome intrinsic and acquired resistance of the tumors during the therapy. For the treatment of breast and prostate cancer steroidal and non-steroidal ligands are available. This article is a crit. review of the attempts made during the last 3 decades to design platinum complexes with a selective mode of action against ...
Zusammenfassung
A review. Platinum complexes with carrier ligands were synthesized to overcome intrinsic and acquired resistance of the tumors during the therapy. For the treatment of breast and prostate cancer steroidal and non-steroidal ligands are available. This article is a crit. review of the attempts made during the last 3 decades to design platinum complexes with a selective mode of action against hormone-dependent tumors. In part 1 of this paper the use of steroidal carrier ligands is described while in part 2 the view is focussed on derivs. of non-steroidal drugs suitable to coordinate to platinum. Esp. the [1,2-diarylethylenediamine]platinum(II) complexes are interesting analogous of cisplatin.
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