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Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents

Von Angerer, Erwin und Knebel, Norbert und Schönenberger, Helmut und Engel, Juergen (1988) Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents.

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Zusammenfassung

The title compds. I [R1 = H, OH, C2-6 alkanoyloxy; R2, R5, R6 = H, halo; R3 = H, C1-6 alkyl; R4 = OH, C2-6 alkanoyloxy; Alk = C2-10 alkylene (4 neighboring CH2 can be replaced by 1,4-phenylene); AB = NHCH2CH2NH2, (H2NCH2)2CH, Q (R7 = H, C1-6 alkyl, Ph); X = equiv. physiol. tolerable anion], useful as antitumor agents with good tolerability, were prepd. by reaction of a tetrahaloplatinum (II) ...

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Dokumentenart:Patent
Datum:1988
Zusätzliche Informationen (Öffentlich):CAN 109:92780 27-11 Heterocyclic Compounds (One Hetero Atom) Patent 19880414 115084-37-2P; 115084-38-3P; 115084-39-4P; 115084-41-8P; 116041-07-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, in synthesis of antitumor platinum complex); 115084-42-9P; 116041-09-9P; 116041-10-2P; 116041-11-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, in synthesis of antitumor platinum complex with indole deriv.); 115140-97-1P; 115140-98-2P; 115140-99-3P; 115141-00-9P; 115141-01-0P; 115141-02-1P; 115160-74-2P; 115160-75-3P; 115357-82-9P; 115357-83-0P; 115357-84-1P; 115357-85-2P; 115357-86-3P; 115357-87-4P; 115357-88-5P; 115357-89-6P; 115357-90-9P; 115362-88-4P; 115378-88-6P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of, as antitumor agent); 107-15-3 (1,2-Ethanediamine); 109-77-3 (Malononitrile); 629-03-8 (1,6-Dibromohexane); 91444-18-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, in synthesis of antitumor platinum complex); 1074-82-4 (Phthalimide potassium); 116041-08-8; 116041-12-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, in synthesis of antitumor platinum complex of indole derivs.) A1 DE 86-3633673 19861003
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1988:492780Andere
87-3730746 3730746Andere
Stichwörter / Keywords:Neoplasm inhibitors (platinum complex of phenylindoles) tumor inhibitor indole platinum complex prepn
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:15 Nov 2010 15:32
Zuletzt geändert:15 Nov 2010 15:32
Dokumenten-ID:18062
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