Startseite UB

Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents

Von Angerer, Erwin and Knebel, Norbert and Schönenberger, Helmut and Engel, Juergen (1988) Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents.

Full text not available from this repository.


Abstract

The title compds. I [R1 = H, OH, C2-6 alkanoyloxy; R2, R5, R6 = H, halo; R3 = H, C1-6 alkyl; R4 = OH, C2-6 alkanoyloxy; Alk = C2-10 alkylene (4 neighboring CH2 can be replaced by 1,4-phenylene); AB = NHCH2CH2NH2, (H2NCH2)2CH, Q (R7 = H, C1-6 alkyl, Ph); X = equiv. physiol. tolerable anion], useful as antitumor agents with good tolerability, were prepd. by reaction of a tetrahaloplatinum (II) ...

plus


Export bibliographical data

Item Type:Patent
Date:1988
Additional information (public):CAN 109:92780 27-11 Heterocyclic Compounds (One Hetero Atom) Patent 19880414 115084-37-2P; 115084-38-3P; 115084-39-4P; 115084-41-8P; 116041-07-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, in synthesis of antitumor platinum complex); 115084-42-9P; 116041-09-9P; 116041-10-2P; 116041-11-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, in synthesis of antitumor platinum complex with indole deriv.); 115140-97-1P; 115140-98-2P; 115140-99-3P; 115141-00-9P; 115141-01-0P; 115141-02-1P; 115160-74-2P; 115160-75-3P; 115357-82-9P; 115357-83-0P; 115357-84-1P; 115357-85-2P; 115357-86-3P; 115357-87-4P; 115357-88-5P; 115357-89-6P; 115357-90-9P; 115362-88-4P; 115378-88-6P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of, as antitumor agent); 107-15-3 (1,2-Ethanediamine); 109-77-3 (Malononitrile); 629-03-8 (1,6-Dibromohexane); 91444-18-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, in synthesis of antitumor platinum complex); 1074-82-4 (Phthalimide potassium); 116041-08-8; 116041-12-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, in synthesis of antitumor platinum complex of indole derivs.) A1 DE 86-3633673 19861003
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1988:492780Other
87-3730746 3730746Other
Keywords:Neoplasm inhibitors (platinum complex of phenylindoles) tumor inhibitor indole platinum complex prepn
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:15 Nov 2010 15:32
Last Modified:15 Nov 2010 15:32
Item ID:18062
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact