Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node. Pharmazie 27 (12), pp. 759-760.
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Measurements of action potentials and stationary voltage-current characteristics on Ranvier nodes of the isolated nervus ischiadicus of Rana esculenta showed that N-(L-N,N-dimethylphenylalanyl)-D-ephedrine [2480-20-8] and N-(D-N,N-dimethylphenylalanyl)-L-ephedrine [7278-68-4] decreased the Na [7440-23-5] cond. of the nodes. The 2 enantiomers of the local anesthetic had approx. the same activity.
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|Additional Information (public):||CAN 78:79588 1-4 Pharmacodynamics 7440-23-5 Role: BIOL (Biological study) (in nerve conductivity at Ranvier node, (dimethylphenylalanyl)ephedrine stereoisomers effect on); 7232-10-2; 7275-84-5 Role: BIOL (Biological study) (nerve conduction at Ranvier node inhibition by, stereospecificity in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Nerve (Ranvier node, (dimethylphenylalanyl)ephedrine stereoisomers inhibition of elec. activity of) nerve sodium cond ephedrine deriv anesthetic nerve sodium cond|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||22 Nov 2010 12:19|
|Last Modified:||22 Nov 2010 12:19|