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Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node. Pharmazie 27 (12), pp. 759-760.

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Abstract

Measurements of action potentials and stationary voltage-current characteristics on Ranvier nodes of the isolated nervus ischiadicus of Rana esculenta showed that N-(L-N,N-dimethylphenylalanyl)-D-ephedrine [2480-20-8] and N-(D-N,N-dimethylphenylalanyl)-L-ephedrine [7278-68-4] decreased the Na [7440-23-5] cond. of the nodes. The 2 enantiomers of the local anesthetic had approx. the same activity.

Item Type:

Article

Additional information (public):

CAN 78:79588 1-4 Pharmacodynamics 7440-23-5 Role: BIOL (Biological study) (in nerve conductivity at Ranvier node, (dimethylphenylalanyl)ephedrine stereoisomers effect on); 7232-10-2; 7275-84-5 Role: BIOL (Biological study) (nerve conduction at Ranvier node inhibition by, stereospecificity in relation to)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Identification Number:

Value	Type
1973:79588	Other

Keywords:

Nerve (Ranvier node, (dimethylphenylalanyl)ephedrine stereoisomers inhibition of elec. activity of) nerve sodium cond ephedrine deriv anesthetic nerve sodium cond

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Unknown

Owner:

Petra Gürster

Deposited On:

22 Nov 2010 13:19