Schönenberger, Helmut and Lippert, P. (1970) Cytostatics 11. Comparative study on the antimicrobial action of tertiary and quaternary beta-aminoketones. Pharmazie 25 (10), pp. 617-620.
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Fungistatic and bacteriostatic activities of some tertiary and quaternary beta -aminoketones were tested against a variety of microorganisms. Greatest activities (relative to that of formaldehyde) were obsd. for 1-dimethylamino-2-phenylbutan-3-one (I), 2-phenyl-3-dimethylaminopropiophenone (II), and their quaternary salts formed with methyl iodide. Quaternization of the beta -aminoketones generally increased the fungistatic activities, the most pronounced effect occurring with 3-diethyl-aminopropiophenone (III). The fungistatic action of the quaternary beta -aminoketones was attributed to their acylethylation reactions with biol. substrates rather than to transaminomethylation.
|Additional information (public):||CAN 74:20718 8 Microbial Biochemistry 91-03-2; 94-38-2; 2543-57-9; 3506-36-3; 5724-15-2; 22563-99-1; 25527-39-3; 28312-41-6; 31034-98-7; 31034-99-8; 31035-03-7; 31035-04-8 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antimicrobial activity of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Molecular structure-biological activity relationships (fungicidal, of quaternary aminoketones) Bactericidal action (of quaternary aminoketones) antimicrobials aminoketones aminoketones antimicrobials quaternary aminoketones fungicides fungicides quaternary aminoketones aminopropiophenones quaternization fungicides propiophenones antimicrobials|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 09:07|
|Last Modified:||19 Nov 2010 09:07|