Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1967) Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type. Pharmaceutica acta Helvetiae 42 (8-10), pp. 593-603.
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The influence of mol. configuration and of pH on the activity of a local anesthetic was detd. by comparing the activities of the 8 stereoisomers of N-(N,N-dimethylphenylalanyl)ephedrine against the isolated ischiadic nerve of frogs and by detg. the median effective dose (ED50) of each stereoisomer required to slow heart ventricle flow rate in frogs by 50% (after 30 min.). The results were as ...
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|Additional information (public):||CAN 67:115443 15 Pharmacodynamics 2480-20-8; 2673-32-7; 5042-94-4; 7232-11-3; 7232-12-4; 7232-12-4; 7275-84-5; 7278-68-4 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Circulation (N-aminoacyl ephedrine derivs. effect on heart) Nerves (blocking agents for, N-aminoacyl ephedrine derivs. as) Heart (circulation in, N-aminoacyl ephedrine derivs. effect on) Anesthesia (from N-aminoacyl ephedrine derivs.) LOCAL ANESTHETICS MOL CONFIGURATION LOCAL ANESTHETICS EPHEDRINES NERVE EFFECT NERVE EFFECT EPHEDRINES RECEPTOR EPHEDRINES BINDING|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 08:58|
|Last Modified:||19 Nov 2010 08:58|