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Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

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Abstract

The function of various mol. groups in anesthetic agents such as N-(N-dimethylalanyl)-2,6-dimethylaniline (I) [19216-39-8], N-(N-dimethylphenylalanyl)-2,6-dimethylaniline [19216-40-1], and N-(N-dimethylphenylalanyl)ephedrine (II) [10385-91-8] and their interaction with structural proteins of innervated membrane (frog heart) was given. Under various pH conditions (6.2-8.3), the anesthetics were ...

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Item Type:Article
Date:1972
Additional information (public):CAN 78:79558 1-3 Pharmacodynamics 2480-20-8; 2673-32-7; 5042-94-4; 7232-10-2; 7232-11-3; 7232-12-4; 7275-84-5; 7278-68-4; 19216-71-8; 19216-72-9; 19216-73-0; 19237-86-6 Role: PROC (Process) (membrane binding of, anesthetic activity in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1973:79558Other
Keywords:Molecular structure-biological activity relationship (anesthetic, of aminoacryldimethylaniline derivs.) Anesthetics (membrane binding of, aminoacryldimethylaniline derivs. in relation to) Membranes (protein, aminoacryldimethylaniline derivs. binding to) Isomerism and Isomers (stereo-, of dimethylphenylalanylephedrine, membrane binding in relation to) anesthetic interaction membrane protein ephedrine isomer anesthesia membrane
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 08:54
Last Modified:19 Nov 2010 08:54
Item ID:18177
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