Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.
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The carcinostatic effects of 7 aminotriazine derivs. [I, R = R1 = NHCH2OH (II), N(CH2OMe)2, NHCH2SO3Na, N(CH2SEt)2, or morpholinomethylamino (III), or R = NHCH2CN, R1 = Cl or NH2] were tested on Yoshida sarcoma and sarcoma 180 in rats. Only N,N',N''-tris(hydroxymethyl)melamine (II) [1017-56-7] had a marked effect. III also inhibited tumor growth, but did not increase the survival time. II and III also had bacteriostatic and fungistatic effects in vitro. II was able to aminomethylate morpholine in vitro under physiol. conditions.
|Additional information (public):||CAN 79:73556 1-5 Pharmacodynamics 1017-56-7; 3089-11-0; 5752-37-4; 5766-69-8; 5766-70-1; 13046-06-5; 50355-82-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Bactericides, Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 08:36|
|Last Modified:||19 Nov 2010 08:36|