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Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds

Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.

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Abstract

The carcinostatic effects of 7 aminotriazine derivs. [I, R = R1 = NHCH2OH (II), N(CH2OMe)2, NHCH2SO3Na, N(CH2SEt)2, or morpholinomethylamino (III), or R = NHCH2CN, R1 = Cl or NH2] were tested on Yoshida sarcoma and sarcoma 180 in rats. Only N,N',N''-tris(hydroxymethyl)melamine (II) [1017-56-7] had a marked effect. III also inhibited tumor growth, but did not increase the survival time. II and III ...

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Item Type:Article
Date:1973
Additional information (public):CAN 79:73556 1-5 Pharmacodynamics 1017-56-7; 3089-11-0; 5752-37-4; 5766-69-8; 5766-70-1; 13046-06-5; 50355-82-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1973:473556Other
Keywords:Bactericides, Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 08:36
Last Modified:19 Nov 2010 08:36
Item ID:18180
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