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Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds

Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.

Full text not available from this repository.

Abstract

The carcinostatic effects of 7 aminotriazine derivs. [I, R = R1 = NHCH2OH (II), N(CH2OMe)2, NHCH2SO3Na, N(CH2SEt)2, or morpholinomethylamino (III), or R = NHCH2CN, R1 = Cl or NH2] were tested on Yoshida sarcoma and sarcoma 180 in rats. Only N,N',N''-tris(hydroxymethyl)melamine (II) [1017-56-7] had a marked effect. III also inhibited tumor growth, but did not increase the survival time. II and III also had bacteriostatic and fungistatic effects in vitro. II was able to aminomethylate morpholine in vitro under physiol. conditions.

Item Type:

Article

Additional information (public):

CAN 79:73556 1-5 Pharmacodynamics 1017-56-7; 3089-11-0; 5752-37-4; 5766-69-8; 5766-70-1; 13046-06-5; 50355-82-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Identification Number:

Value	Type
1973:473556	Other

Keywords:

Bactericides, Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Unknown

Owner:

Petra Gürster

Deposited On:

19 Nov 2010 09:36