Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.
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The carcinostatic effects of 7 aminotriazine derivs. [I, R = R1 = NHCH2OH (II), N(CH2OMe)2, NHCH2SO3Na, N(CH2SEt)2, or morpholinomethylamino (III), or R = NHCH2CN, R1 = Cl or NH2] were tested on Yoshida sarcoma and sarcoma 180 in rats. Only N,N',N''-tris(hydroxymethyl)melamine (II) [1017-56-7] had a marked effect. III also inhibited tumor growth, but did not increase the survival time. II and III ...
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|Additional information (public):||CAN 79:73556 1-5 Pharmacodynamics 1017-56-7; 3089-11-0; 5752-37-4; 5766-69-8; 5766-70-1; 13046-06-5; 50355-82-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Bactericides, Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Nov 2010 08:36|
|Last Modified:||19 Nov 2010 08:36|