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Effects of N-aminoacylephedrines, a new class of local anesthetics. Synthesis of local anesthetics with pressor activity

Schönenberger, Helmut and Sieckmann, W. and Brinkmann, Rolf (1967) Effects of N-aminoacylephedrines, a new class of local anesthetics. Synthesis of local anesthetics with pressor activity. Arzneimittel-Forschung = Drug research 17 (6), pp. 744-747.

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Abstract

cf. CA 62: 7857h. Among a group of N-aminoalanylephedrines, those with stronger anesthetic power than procaine in rabbit corneas were N-[D-(N,N - dimethylphenylalanyl)] - L - amphetamine, N - [D - (N,N-dimethylphenylalanyl)] - D - ephedrine, N - [D - (N,N - dimethylphenylalanyl(] - L - y - ephedrine, and N - [L - (N,N - dimethylphenylalanyl)]-D-yephedrine. All were more toxic than L-ephedrine.

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Article

Additional information (public):

CAN 67:115574 15 Pharmacodynamics 17708-27-9; 17708-28-0; 17708-29-1; 17708-30-4; 17708-31-5; 17708-32-6; 17708-33-7; 17708-34-8; 17708-42-8; 17708-43-9; 17708-44-0; 17708-45-1; 17708-46-2; 17708-47-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

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