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Zinc(II)cyclen–peptide conjugates interacting with the weak effector binding state of Ras

Schmidt, F. and Rosnizeck, I. C. and Spoerner, M. and Kalbitzer, Hans Robert and König, Burkhard (2011) Zinc(II)cyclen–peptide conjugates interacting with the weak effector binding state of Ras. Inorganica chimica acta: Inorg. Chim. Acta 365 (1), pp. 38-48.

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Abstract

Zinc(II)cyclen–peptide hybrid compounds and bis-zinc(II)cyclen complexes are prepared as potential binders of the guanine nucleotide binding protein Ras, an important molecular switch in cellular signal transduction. The design of the compounds is based on the previous observation that zinc(II)cyclen complexes could serve as lead compounds for inhibitors of Ras-effector interaction and thus be ...

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Item Type:Article
Date:2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
10.1016/j.ica.2010.07.067DOI
Keywords:Ras protein, Zinc cyclen, Protein–protein inhibition, Metal complex, NMR
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:04 Jan 2011 10:54
Last Modified:04 Jan 2011 10:54
Item ID:18895
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