Schmidt, F. and Rosnizeck, I. C. and Spoerner, M. and Kalbitzer, Hans Robert and König, Burkhard (2011) Zinc(II)cyclen–peptide conjugates interacting with the weak effector binding state of Ras. Inorganica chimica acta: Inorg. Chim. Acta 365 (1), pp. 38-48.
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Zinc(II)cyclen–peptide hybrid compounds and bis-zinc(II)cyclen complexes are prepared as potential binders of the guanine nucleotide binding protein Ras, an important molecular switch in cellular signal transduction. The design of the compounds is based on the previous observation that zinc(II)cyclen complexes could serve as lead compounds for inhibitors of Ras-effector interaction and thus be ...
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|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König|
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
|Keywords:||Ras protein, Zinc cyclen, Protein–protein inhibition, Metal complex, NMR|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||04 Jan 2011 10:54|
|Last Modified:||04 Jan 2011 10:54|