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Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome

Tzankov, Alexandar and Gschwendtner, Andreas and Augustin, Florian and Fiegl, Michael and Obermann, Ellen C. and Dirnhofer, Stephan and Went, Philip (2006) Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome. Clinical cancer research : an official journal of the American Association for Cancer Research 12 (7 Pt 1), pp. 2125-2132.

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Other URL: http://dx.doi.org/10.1158/1078-0432.CCR-05-2135


Abstract

PURPOSE: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an ...

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Item Type:Article
Date:1 April 2006
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1158/1078-0432.CCR-05-2135DOI
16609025PubMed ID
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:29 Mar 2007
Last Modified:13 Mar 2014 10:10
Item ID:1946
Owner Only: item control page
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