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Induction of a MHC class I-restricted, CD8 positive cytolytic T-cell response by chimeric HIV-1 virus-like particles in vivo: implications on HIV vaccine development

Wagner, Ralf and Deml, L. and Schirmbeck, R. and Reimann, J. and Wolf, Hans J. (1994) Induction of a MHC class I-restricted, CD8 positive cytolytic T-cell response by chimeric HIV-1 virus-like particles in vivo: implications on HIV vaccine development. Behring-Institute-Mitteilungen = Behring Institute research communications (95), pp. 23-34.

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Abstract

New insights into HIV-pathogenesis suggest that the cell mediated immune response might play a crucial role in controlling HIV infection by suppressing HIV-replication in CD4-positive cells by a lymphokine-like soluble factor and by killing HIV-infected cells via classical CTL mediated lysis. This type of a cellular immune response rather than an antibody response seems to be most promising to ...

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Item Type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
7755506PubMed ID
Classification:
NotationType
AIDS VaccinesMESH
Acquired Immunodeficiency Syndrome/prevention & controlMESH
Amino Acid SequenceMESH
AnimalsMESH
Drug DesignMESH
Gene Products, gag/immunologyMESH
HIV Envelope Protein gp120/immunologyMESH
HIV Infections/prevention & controlMESH
HIV-1/physiologyMESH
Histocompatibility Antigens Class I/immunologyMESH
HumansMESH
Major Histocompatibility ComplexMESH
Molecular Sequence DataMESH
Peptide Fragments/immunologyMESH
Recombinant Fusion Proteins/immunologyMESH
T-Lymphocytes, Cytotoxic/immunologyMESH
Virus ReplicationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:06 Apr 2011 07:50
Last Modified:13 Mar 2014 17:13
Item ID:20388
Owner Only: item control page

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