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Modular Synthesis of Triazole-Containing Triaryl α-Helix Mimetics

Ehlers, I. and Maity, P. and Aube, J. and König, Burkhard (2011) Modular Synthesis of Triazole-Containing Triaryl α-Helix Mimetics. European Journal of Organic Chemistry, pp. 2474-2490.

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Abstract

We describe novel scaffold designs for nonpeptidic α-helix mimetics. The tricyclic scaffolds contain triazoles and reproduce amino acid side chains i, i+3, and i+7. The three different scaffolds are synthetically readily accessible, allow the introduction of further substituents to increase the versatility,and are suitable for library design. A modular synthesis route using Cu I- and Ru ...

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Item Type:Article
Date:2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/ejoc.201001531DOI
Keywords:Helical structures / Peptidomimetics / Click chemistry / Nitrogen heterocycles / Protein-protein interactions
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:27 Apr 2011 06:25
Last Modified:02 Nov 2011 09:45
Item ID:20613
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